Biobytes

Multi-Level Organization of Biological Systems
Somdatta Sinha

A system consists of components (or, elements), which are interacting, interrelated, or energy to form a complex “whole”. In other words, it is an assemblage of inter-related elements ...more

Systems Biology – Connecting Genotype to Phenotype
KV Venkatesh

The beginning of last century brought in fundamental understanding of the physical and chemical world through advances in chemistry and physics. These advances led to .. more

Biology as Rules of Interaction

K. V. S. Prasad

Interaction is characteristic of life, whether between an organism and its environment, or between different subsystems of an organism,and so on all the way down to molecular interactions. One computational abstraction of a ... more

Biological systems are enormously complex, organised across several levels of hierarchy. Despite this complexity, life thrives in a variety of environments, exhibits bewildering .... more

Flows in complex biochemical networks: Role of low degree nodes
Areejit Samal, and Sanjay Jain

Metabolic networks have two properties that are generally regarded as unrelated: One, they have metabolic reactions whose single knockout is lethal for the organism, and two, they ... more

Whole cell simulation using E-Cell software
Srividhya K V and Krishnaswamy S

Rapid accumulation of biological data from genome, proteome, transcriptome and metabolome projects are useful for construction and analysis of virtual cells in silico... more

Mycobacterium tuberculosis systems biology data in R
Srinivasan Ramachandran, et.al.,

M. tuberculosis is a dreaded pathogen causing the respiratory disease Tuberculosis with high rates of mortality (approximately 1 death per 1.5 min. in India alone). The rate of ...more

Systems Biology of Malaria: An Indian Perspective
Ashis Das, Dhanpath Kochar and Utpal Tatu

Malaria is a prehistoric disease. It is believed that malaria may have contributed to extinction of dinosaurs from the earth. There is documentation of malaria in our old ...more

Dynamic virtual prototype of Parkinson’s disease at the cellular and molecular abstraction level: Focus on neurodegeneration physiology
Shireen Vali and M.M. Srinivas Bharath

Rising prevalence of neurodegenerative disorders has compelled detailed studies to understand their pathophysiology t the molecular level to evolve innovative diagnostic and therapeutic strategies. Parkinson’s ... more

Systems-level modelling of Mycobacterium tuberculosis for anti-tubercular drug target identification
Karthik Raman, Kalidas Yeturu, Ashwini Bhat and Nagasuma Chandra

Systems biology adopts an integrated approach to study and understand the function of ....more